Benzyl 4-(aminocarbonyl)piperidine-1-carboxylate

Benzyl 4-(aminocarbonyl)piperidine-1-carboxylate - Names and Identifiers

Name	BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
Synonyms	N-Z-ISONIPECOTINAMIDE 1-Cbz-4-piperidinecarboxamide 1-N-CBZ-PIPERIDINE-4-CARBOXAMIDE benzyl 4-carbamoylpiperidine-1-carboxylate Benzyl 4-(aminocarbonyl)piperidine-1-carboxylate 4-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 1-Piperidinecarboxylic acid, 4-(aminocarbonyl)-, phenylmethyl ester
CAS	167757-45-1
InChI	InChI=1/C14H18N2O3/c15-13(17)12-6-8-16(9-7-12)14(18)19-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H2,15,17)

Benzyl 4-(aminocarbonyl)piperidine-1-carboxylate - Physico-chemical Properties

Molecular Formula	C14H18N2O3
Molar Mass	262.3
Density	1.224±0.06 g/cm3(Predicted)
Melting Point	130 °C
Boling Point	475.5±44.0 °C(Predicted)
Flash Point	241.4°C
Vapor Presure	3.3E-09mmHg at 25°C
pKa	16.40±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.568
MDL	MFCD01568760

Benzyl 4-(aminocarbonyl)piperidine-1-carboxylate - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Benzyl 4-(aminocarbonyl)piperidine-1-carboxylate - Introduction

BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE is an organic compound with the chemical formula C19H19N3O2. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE is a white to yellowish solid.
-Solubility: It can be dissolved in some organic solvents (such as dimethylformamide and chloroform), but its solubility in water is low.
-Melting Point: its melting point is about 140-145 ℃.

Use:
- BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE has certain applications in the field of medicinal chemistry. It can be used as an intermediate in the synthesis of bioactive molecules for the preparation of anti-tumor and anti-infection drugs.
-It can also be used as a protecting group (protecting hydroxyl group) or activating agent in organic synthesis.

Method:
The preparation of-BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE can be obtained by reacting piperidine with formyl chloride. First, piperidine is Ketal with formic acid under basic conditions to form an N-formylated intermediate, which is then chlorinated with thionyl chloride to form the ring at the C4 position. Finally, this intermediate was reacted with BENZYL benzoate to give BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE.

Safety Information:
- BENZYL 4-(AMINOCARBONYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE has no obvious toxicity or danger under normal use conditions.
-But in the process of operation, still need to pay attention to the following matters:
-Avoid contact with skin and wear suitable protective gloves, goggles, etc.
-avoid inhalation of its dust or steam, the use of the need to maintain good ventilation conditions.
-Do not eat or drink during operation, and avoid eating by mistake.
-Follow proper laboratory procedures and personal protective measures when using or handling the compound.

Last Update：2024-04-09 21:01:54